Premier League champions, Manchester City, have been paired with 13-time winners, Real Madrid, in the last 16 draw of the UEFA Champions League on Monday.
Holders, Liverpool, will face 2013 finalist, Atletico Madrid, for a place in the quarter-finals, in the bid to defend their title.
Chelsea, who won the trophy for the first time in their history in 2012, will face German champions, Bayern Munich.
Lionel Messi’s Barcelona will seek to make up for the manner they lost to Liverpool in the semi-final of the competition last season, when they face Italian side, Napoli, for a place in the last eight.
Paris Saint-Germain will battle Bundesliga side, Borussia Dortmund, as they continue to covet the prestigious trophy, which they have not won in their history.
Italian champions, Juventus, have a date with Olympique Lyonnais, while first timers, Atalanta, will hope to make history when they face Valencia.
Last season finalist, Tottenham Hotspur, now being coached by Jose Mourinho, face RB Leipzig.